投稿指南
一、稿件要求: 1、稿件内容应该是与某一计算机类具体产品紧密相关的新闻评论、购买体验、性能详析等文章。要求稿件论点中立,论述详实,能够对读者的购买起到指导作用。文章体裁不限,字数不限。 2、稿件建议采用纯文本格式(*.txt)。如果是文本文件,请注明插图位置。插图应清晰可辨,可保存为*.jpg、*.gif格式。如使用word等编辑的文本,建议不要将图片直接嵌在word文件中,而将插图另存,并注明插图位置。 3、如果用电子邮件投稿,最好压缩后发送。 4、请使用中文的标点符号。例如句号为。而不是.。 5、来稿请注明作者署名(真实姓名、笔名)、详细地址、邮编、联系电话、E-mail地址等,以便联系。 6、我们保留对稿件的增删权。 7、我们对有一稿多投、剽窃或抄袭行为者,将保留追究由此引起的法律、经济责任的权利。 二、投稿方式: 1、 请使用电子邮件方式投递稿件。 2、 编译的稿件,请注明出处并附带原文。 3、 请按稿件内容投递到相关编辑信箱 三、稿件著作权: 1、 投稿人保证其向我方所投之作品是其本人或与他人合作创作之成果,或对所投作品拥有合法的著作权,无第三人对其作品提出可成立之权利主张。 2、 投稿人保证向我方所投之稿件,尚未在任何媒体上发表。 3、 投稿人保证其作品不含有违反宪法、法律及损害社会公共利益之内容。 4、 投稿人向我方所投之作品不得同时向第三方投送,即不允许一稿多投。若投稿人有违反该款约定的行为,则我方有权不向投稿人支付报酬。但我方在收到投稿人所投作品10日内未作出采用通知的除外。 5、 投稿人授予我方享有作品专有使用权的方式包括但不限于:通过网络向公众传播、复制、摘编、表演、播放、展览、发行、摄制电影、电视、录像制品、录制录音制品、制作数字化制品、改编、翻译、注释、编辑,以及出版、许可其他媒体、网站及单位转载、摘编、播放、录制、翻译、注释、编辑、改编、摄制。 6、 投稿人委托我方声明,未经我方许可,任何网站、媒体、组织不得转载、摘编其作品。

Nutritional status changes in patients with

来源:吉林大学社会科学学报 【在线投稿】 栏目:期刊导读 时间:2020-12-21
作者:网站采编
关键词:
摘要:Non-small cell lung cancer (NSCLC) is the most common cancer and the major cause of cancer-related deaths in China and globally [1]. Systemic chemotherapy is the mainstream treatment for metastatic NSCLC without a driving gene, with an obje

Non-small cell lung cancer (NSCLC) is the most common cancer and the major cause of cancer-related deaths in China and globally [1]. Systemic chemotherapy is the mainstream treatment for metastatic NSCLC without a driving gene, with an objective tumor response rate of 25–35% [2]. At cancer diagnosis, approximately 50% of patients present with some nutritional deficits [3].This prevalence may even rise depending on the tumor location and stage. The highest prevalence is noted in patients with tumors of the gastrointestinal tract and the lungs [4].

Systemic administration of chemotherapy agents targets rapidly dividing cells, including those in the bone marrow and gastrointestinal tract epithelial direct effects of chemotherapy agents can result in gastrointestinal toxicities, which in turn affect the nutritional statuses of patients [5]. Chemotherapy-induced nausea, vomiting, diarrhea, constipation, anorexia, taste disorder, and early satiety are the symptoms commonly reported by patients undergoing chemotherapy [6]. A subset of these patients may experience the symptoms to an extent that limits their dietary intake, and their nutritional statuses may be compromised, leading to negative outcomes for patients and treatment facilities [7].Malnourished patients experience decreased quality of life, diminished treatment tolerance, increased number of complications, and prolonged hospital admissions,all of which jeopardize treatment adherence and tumor control and ultimately increase the mortality and healthcare burden [8]. Therefore, detecting malnutrition early in patients with cancer has become increasingly important.

Nutritional screening includes anthropometric parameters [body mass index (BMI) and weight loss percentage] and biochemical parameters [hemoglobin(Hb) and albumin] [9-12]. Gastrointestinal symptoms,weight loss, and Hb and albumin levels often decrease in patients receiving chemotherapy [13]. An easy routine screening of malnutrition in patients with cancer should include these factors.

The current study aimed to assess the reallife nutritional status changes and gastrointestinal symptoms in patients with advanced NSCLC receiving chemotherapy.

Materials and methods

This cross-sectional study was conducted at the Cancer Centre, Tongji Hospital, Tongji Medical College,Huazhong University of Science and Technology,between January 2016 and January 2017. Informed consent was obtained from all participants. Biochemical and clinical data were assessed before the first chemotherapy cycle and after the second chemotherapy cycle.

The selection criteria were as follows: age between 19 and 75 years and pathological diagnosis of stage IV NSCLC. Meanwhile, patients who underwent any surgery or radiotherapy as treatment were excluded from the study. The present research was conducted in accordance with the guidelines in the Declaration of Helsinki, and all procedures involving human subjects/patients were approved by the ethics committee.

Data analysis

Descriptive statistics were used for the qualitative and quantitative variables, frequency, percentage, mean,and standard deviation (SD). The average distance of the groups was compared using the paired-samples t analysis was performed using the SPSS software,version 18 (SPSS, Inc., USA). P < 0.05 was considered statistically significant.

Table 1 General characteristics (mean values and standard deviations; number of patients and percentage values)Variables n %Sex Male 70 67.31 Femal 34 32.69 Age (years)Mean 54.57 SD 9.32 Weight (kg)Mean 62.28 SD 10.05 BMI (kg/m2)Mean 22.98 SD 3.19 Weight loss (kg)Mean 2.38 SD 2.85 Weight loss≥ 5 32 30.77≥ 10 13 12.50

Results

General characteristics

A total of 104 patients with advanced NSCLC [34(32.69%) women and 70 (67.31%) men] underwent at least two chemotherapy cycles. The mean age was 54.57 (SD 14.8) years. The mean body weight was 62.28± 10.46 kg, and the mean BMI was 22.98 ± 3.19 kg/m2(Table 1).

Unintentional weight loss before chemotherapy

Over 65.38% (68/104) of the patients experienced unintentional weight loss, whereas 30.77% and 12.50% showed ≥ 5% and ≥ 10% degrees of weight loss, respectively, within 6 months before firstline chemotherapy was administered (Table 1).Unintentional weight loss > 10% in the preceding 6 months was considered a sign of malnutrition.

Gastrointestinal symptoms during chemotherapy

The most common gastrointestinal symptoms reported among all the study patients were anorexia(80/104, 76.92%), nausea (53/104, 50.96%), constipation(49/104, 47.12%), vomiting (48/104, 46.15%), taste disorders (40/104, 38.46%), early satiety (32/104,30.77%), diarrhea (13/104, 12.50%), and dysphagia(2/104, 1.92%; Table 2).

Table 2 Gastrointestinal symptoms reported during chemotherapySymptoms n %Anorexia 80 76.92 Nausea 53 50.96 Constipation 49 47.12 Vomiting 48 46.15 Taste disorders 40 38.46 Early satiety 32 30.77 Diarrhoea 13 12.50 Dysphagia 2 1.92

文章来源:《吉林大学社会科学学报》 网址: http://www.jldxshkxxb.cn/qikandaodu/2020/1221/461.html



上一篇:公共卫生视野下的健康传播及其效果评价
下一篇:艰且益坚 不负初心

吉林大学社会科学学报投稿 | 吉林大学社会科学学报编辑部| 吉林大学社会科学学报版面费 | 吉林大学社会科学学报论文发表 | 吉林大学社会科学学报最新目录
Copyright © 2018 《吉林大学社会科学学报》杂志社 版权所有
投稿电话: 投稿邮箱: